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5 Pharmacology of intranasal chelators The route of administration significantly affects the pharmacokinetics, efficacy, and toxicity of iron chelator therapy for CNS disorders

Several limitations and challenges must be addressed for the clinical translation of UA as follows

In recent years, a wide range of alternative green extraction technologies has been practiced including a biotechnological approach (microbial fermentation and enzymatic hydrolysis) and non-thermal techniques (high hydrostatic pressure, supercritical/subcritical, ultrasound, and microwave-assisted extraction methods) (Singh et al., 2022

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